All the advantages of the V3 implant with the added plus of the B+ treatment.

B+. Now available with the advanced C1 conical connection implant.

B for Biology.

Fractures at the interface (control) after implant removal.

Proven to eliminate the micro-gap, accelerating primary and biological stability.

Process of bone formation on a multi-phosphonate treated implant at 2 weeks healing in sheep.

Bone formation only 8 weeks after placement of B+ treated implants.

Studies show that removal of B+ treated implants led to breakage in the bone as opposed to the implant-bone contact point.

When titanium and bone synthesize

OVERVIEW

OVERVIEW

B+ is a biological feature of MIS implants, that results in effective, long-term osseointegration. A mono-molecular layer of multi phosphonates is permanently bound to the surface of the implant, which is perceived as bone-like by the body.

The technology has been clinically demonstrated to result in vis-ible bone growth directly on the surface of the B+ implant. The characteristics of B+ promote enhanced clinical performance with the possibility for earlier loading of the implant, better preservation of the bone levels around the implant, and longer-term implant survival, even in patients with compromised bone healing situations.

Molecules of B+ chemically bind to the implant surface, creating a hydrophilic surface, and remain stable throughout the life span of the implant. B+ features provide superior bone healing and implant integration. The phosphonated molecules have demonstrated high stability in terms of chemical and enzymatic degradation. These properties prevent the molecules from detaching from the implant surface, which allows them to remain present for the lifespan of the implant, providing bone attachment throughout each successive bone remodeling cycle.

This novel, phosphonate rich surface mimics one of the main constituents of bone, providing a significantly more favorable environment for implant integration. It has also been observed to accelerate the healing process, eliminate the “micro gap” between the bone and implant surface, and increase the fixation of the implant in bone.


ADVANTAGES

ADVANTAGES

Hydrophilicity
 

Current literature demonstrates a linkage between improved bone healing and early osseointegration with the Hydrophilicity of surface. MIS implant surface treatment combines sand-blasting and acid-etching. This ensures surface purity and Hydrophilic properties. B+ enhances the wettability of the implant surface, attracting water, proteins, and cells from the blood, enabling quicker cell adhesion and colonization, which results in faster bone matrix formation and osseointegration. The Bone cells perceive the B+ treated implants as “bone” and thus migrate onto these surfaces very quickly.

Biomechanical Fixation
 

Once on the implant surface, a new bone matrix is quickly formed, maturing to organized, mineralized bone. The biomimetic characteristics of B+ allow for greater implant integration at earlier stages leading to long-term optimal osseointegration. The increased number of bone cells in contact with the B+ implant results in enhanced biomechanical implant fixation very early on in the healing process. Increased fixation with B+ has been observed to reduce healing time.

Elimination of the “Micro-Gap”
 

In addition to mechanical interlocking resulting from the implant’s roughened topography, B+ also provides a chemical connection between bone and implant surface, eliminating the “micro-gap”. This results in early functional implant stability and fixation.

Stability in a Physiological Environment
 

The B+ molecule was shown to remain permanently bound to the implant surface throughout osseointegration, inflammation, and remodeling events. Furthermore unlike phosphates, phosphonated molecules such as B+ are enzymatically stable, ensuring that B+ will remain attached to the implant, and will not be released into the body over time.

RESEARCH

RESEARCH

The following published research articles demonstrate the safety and efficacy of B+ treated implants as presented following pre-clinical studies.

CLOSE
A NOVEL MULTI-PHOSPHONATE SURFACE TREATMENT OF TITANIUM DENTAL IMPLANTS: A STUDY IN SHEEP
 

Abstract:

The aim of the present study was to evaluate a new multi-phosphonate surface treatment (SurfLink®) in an unloaded sheep model. Treated implants were compared to control implants in terms of bone to implant contact (BIC), bone formation, and biomechanical stability.
The study used two types of implants (rough or machined surface finish) each with either the multi-phosphonate Wet or Dry treatment or no treatment (control) for a total of six groups. Animals were sacrificed after 2, 8, and 52 weeks. No adverse events were observed at any time point.

At two weeks, removal torque showed significantly higher values for the multi-phosphonate treated rough surface (+32% and +29%, Dry and Wet, respectively) compared to rough control.

At 52 weeks, a significantly higher removal torque was observed for the multi-phosphonate treated machined surfaces (+37% and 23%, Dry and Wet, respectively).

The multi-phosphonate treated groups showed a positive tendency for higher BIC with time and increased new-old bone ratio at eight weeks.

SEM images revealed greater amounts of organic materials on the multi-phosphonate treated compared to control implants, with the bone fracture (from the torque test) appearing within the bone rather than at the bone to implant interface as it occurred for control implants.

See the article >



SAFETY AND EFFICACY OF A BIOMIMETIC MONOLAYER OF PERMANENTLY BOUND MULTI-PHOSPHONIC ACID MOLECULES ON DENTAL IMPLANTS: 1 YEAR POST-LOADING RESULTS FROM A PILOT QUADRUPLE-BLINDED RANDOMISED CONTROLLED TRIAL
 

Purpose:

To evaluate the safety and clinical efficacy of a novel surface treatment (SurfLink®, Nano Bridging Molecules, Gland, Switzerland) on titanium dental implants. SurfLink consists of a monolayer of permanently bound multi-phosphonic acid molecules, which mimics the surface of naturally occurring hydroxyapatite.


Materials and methods:

Twenty-three patients requiring at least two single dental implants had their sites randomised according to a split-mouth design to receive one titanium grade 4 implant treated with SurfLink and one untreated control implant. Additional SurfLink-treated implants were placed if needed. Implants were submerged for 3 months in mandibles and 6 months in maxillae, were loaded with definitive metal-ceramic crowns, and followed up for 1 year after loading. Outcome measures were crown/implant failures, any complication, radiographic peri-implant marginal bone level changes and marginal bleeding.


Results:

One patient dropped out after abutment connection. All remaining patients were followed up to 1 year post-loading. No implant failed and only 1 postoperative complication (pain) occurred, but it may not have been related to the implant treatment. No bleeding was observed when a periodontal probe was used to examine the peri-implant soft tissues around the implants. There were no statistically significant differences in marginal bone level changes between the two groups (P = 0.057, mean difference = -0.27, SE= 0.13; 95% Cl -0.55 to 0.01).


Conclusions:

Preliminary short-term data (1 year post-loading) of implants with a biomimetic monolayer of permanently bound multi-phosphonic acid molecules (SurfLink surface treatment) presented no safety issues. Clinical healing in both the control and SurfLink-treated implant group was uneventful and did not differ significantly between groups. More challenging clinical situations need to be investigated to evaluate the real effectiveness of this surface treatment.

See the article >



SEM ANALYSIS OF OSSEOINTEGRATED PHOSPHOROUS RICH IMPLANTS AFTER 52 WEEKS IN SHEEP PELVIS
 

Aim:

The surface of dental implants determines the initial phases of the biological response and affects its ability to integrate into the surrounding tissue.
Covalently binding a monolayer of phosphorous rich molecules (SurfLink) to well established surface modifications (sandblasting, acid-etching) offers new dimensions of osseointegration. The aim of this study is to present the surface analysis of SurfLink implants using Scanning Electron Microscopy (SEM) and elemental analysis (EDX).


Material and Methods:

Machined and roughened dental implants with either SurfLink treatment or no treatment (control) were placed in the pelvis of 24 sheep. Selected implants, retrieved after 52 weeks healing, previously used for removal torque testing, were analyzed by SEM and EDX (Phenom ProX SEM, high-sensitivity backscattered electron detector for topographical mode and thermoelectrically cooled Silicon Drift Detector for EDX).


Results:

SurfLink implants showed increased bone coverage on the machined and roughened surfaces compared to control implants. The presence of mineralized fibrous structures was evidenced by significant Ca and P peaks detected by EDX, with bone cells on the SurfLink implant surface. The machined control implant showed a nearly bare titanium surface. Fracture lines after torque testing occurred at the bone-implant interface in the control group, while the SurfLink implants showed a fracture line within the bone, indicating the absence of the typical proteoglycan layer.


Conclusion:

SEM images of SurfLink implants showed fractures within the bone and not at the bone-implant interface. This suggests a significant increase in bone adhesion on SurfLink surfaces. Clinically this results in improved implant stability especially in the early phases of osseointegration.

See the article >



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